{"id":1974,"date":"2022-11-24T06:03:51","date_gmt":"2022-11-24T06:03:51","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=1974"},"modified":"2023-03-17T06:23:19","modified_gmt":"2023-03-17T06:23:19","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e3%80%8a%e6%96%b0%e8%8b%b1%e6%a0%bc%e5%85%b0%e5%8c%bb%e5%ad%a6%e6%9d%82%e5%bf%97%e3%80%8b%e5%8f%91%e8%a1%a8%e5%8f%a3%e6%9c%8d%e6%8a%97%e6%96%b0","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e3%80%8a%e6%96%b0%e8%8b%b1%e6%a0%bc%e5%85%b0%e5%8c%bb%e5%ad%a6%e6%9d%82%e5%bf%97%e3%80%8b%e5%8f%91%e8%a1%a8%e5%8f%a3%e6%9c%8d%e6%8a%97%e6%96%b0\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u5ba3\u5e03\u5df2\u5411\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\u63d0\u4ea4\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>\u8fd9\u662f\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u6b27\u6d32\u5730\u533a\u7684\u7b2c\u4e8c\u9879\u4e0a\u5e02\u7533\u8bf7\uff0c\u5176\u5168\u7403\u5546\u4e1a\u5316\u5de5\u4f5c\u6b63\u5728\u7a33\u6b65\u63a8\u8fdb<\/em><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5317\u4eac\u65f6\u95f42022\u5e7411\u670824\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u4e8e\u8fd1\u65e5\u5411\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u63d0\u4ea4\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u3002\u6b64\u6b21\u7533\u62a5\u7684\u9002\u5e94\u75c7\u5206\u522b\u4e3a\uff1a1\uff09\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b2\uff09\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\uff08ESCC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u6b64\u524d\uff0c\u541b\u5b9e\u751f\u7269\u5df2\u5411\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u63d0\u4ea4\u4e86\u8fd9\u4e24\u9879\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u3002<\/p>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u533b\u5b66\u5b98Patricia Keegan\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u672c\u6708\uff0c\u6211\u4eec\u5148\u540e\u5411\u6b27\u6d32\u4e24\u5927\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u8fd9\u4f53\u73b0\u4e86\u516c\u53f8\u81f4\u529b\u63a8\u52a8\u521b\u65b0\u836f\u7269\u9020\u798f\u5168\u7403\u60a3\u8005\u7684\u575a\u5b9a\u51b3\u5fc3\u4ee5\u53ca\u9ad8\u6548\u7684\u6267\u884c\u529b\u3002\u540e\u7eed\u6211\u4eec\u5c06\u4e0e\u82f1\u56fd\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u7d27\u5bc6\u5408\u4f5c\uff0c\u79ef\u6781\u63a8\u52a8\u65b0\u5174\u7597\u6cd5\u5728\u5f53\u5730\u7684\u4e34\u5e8a\u5f00\u53d1\u4e0e\u5e94\u7528\u3002\u201d<\/p>\n\n\n\n<p>\u6b64\u6b21NPC\u548cESCC\u9002\u5e94\u75c7\u7684\u7533\u62a5\u5206\u522b\u57fa\u4e8eJUPITER-02\uff08\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0cNCT03581786\uff09\u548cJUPITER-06\uff08\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u7814\u7a76\uff0cNCT03829969\uff09\u7684\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n\n\n\n<p>JUPITER-02\u6210\u679c\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u7684\u5168\u4f53\u5927\u4f1a\u4e0a\u9996\u6b21\u53d1\u8868\uff08#LBA2\uff09\uff0c\u968f\u540e\u4f5c\u4e3a<a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01444-0\">\u300a\u81ea\u7136-\u533b\u5b66\u300b<\/a>\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a87.241\uff092021\u5e749\u6708\u520a\u7684\u5c01\u9762\u6587\u7ae0\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u4e8e\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027NPC\u60a3\u8005\uff0c\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u663e\u8457\u5ef6\u957f\uff0c\u4e3a21.4 vs. 8.2\u4e2a\u6708\uff0c\u5ef6\u957f13.2\u4e2a\u6708\uff0c\u5e76\u4e14\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u964d\u4f4e48%\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\uff08HR=0.52\uff0c95%CI\uff1a0.37-0.73\uff0c\u53cc\u4fa7p<0.0001\uff09\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u665a\u671fNPC\u4e00\u7ebf\u548c\u540e\u7ebf\u6cbb\u7597\u7684\u4e24\u9879\u9002\u5e94\u75c7\u5df2\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u8be5\u9886\u57df\u6cbb\u7597\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u3002\u5728\u56fd\u9645\u4e0a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7684NPC\u9002\u5e94\u75c7\u66fe\u88ab\u7f8e\u56fd\u548c\u6b27\u76df\u76d1\u7ba1\u673a\u6784\u7d2f\u8ba1\u6388\u4e882\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c2\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u7f8e\u56fd\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u6b63\u5728\u5ba1\u8bc4\u4e2d\uff0c\u6709\u671b\u6210\u4e3a\u8be5\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u7528\u4e8e\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u836f\u7269\u3002<\/p>\n\n\n\n<p>JUPITER-06\u6210\u679c\u5219\u5728\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5e74\u4f1a\uff08ESMO 2021\uff09\u4e0a\u4ee5\u53e3\u5934\u6c47\u62a5\u5f62\u5f0f\u9996\u6b21\u4eae\u76f8\uff0c\u968f\u540e\u5728\u56fd\u9645\u9876\u5c16\u80bf\u7624\u5b66\u6742\u5fd7<a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(22)00059-9\">\u300aCancer Cell\u300b<\/a>\uff08\u5f71\u54cd\u56e0\u5b50\uff1a38.585\uff09\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u672a\u7ecf\u7cfb\u7edf\u6027\u5316\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u8ba9\u66f4\u591a\u60a3\u8005\u83b7\u5f97\u4e86\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u5176\u4e2d\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5927\u5e45\u5ef6\u957f\u81f317\u4e2a\u6708\uff0c\u5bf9\u6bd4\u5bf9\u7167\u7ec4\u5355\u7eaf\u5316\u7597\u5ef6\u957f\u4e866\u4e2a\u6708\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e42%\uff08HR=0.58\uff0cP\uff1c0.0001\uff09\uff0c\u4e14\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u5982\u4f55\uff0c\u5747\u53ef\u83b7\u76ca\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u665a\u671fESCC\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u98df\u7ba1\u764c\u4e5f\u66fe\u83b7\u5f97\u7f8e\u56fd\u76d1\u7ba1\u673a\u6784\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\"><em>2. <\/em><em>\u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n\n\n<p><strong>\u5173\u4e8e\u9f3b\u54bd\u764c<\/strong><\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u79cd\u539f\u53d1\u4e8e\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u6076\u6027\u80bf\u7624\uff0c\u662f\u5e38\u89c1\u7684\u5934\u9888\u90e8\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7edf\u8ba1\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc713\u4e07<sup>[1]<\/sup>\u3002\u7531\u4e8e\u539f\u53d1\u80bf\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u91c7\u7528\u624b\u672f\u6cbb\u7597\uff0c\u5c40\u90e8\u75be\u75c5\u60a3\u8005\u4e3b\u8981\u91c7\u7528\u5316\u7597\u53ca\u653e\u7597\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\uff0c\u76ee\u524d\u5c1a\u65e0\u836f\u7269\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u9f3b\u54bd\u764c\uff0c\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u4e00\u7ebf\u6807\u51c6\u7597\u6cd5\uff08\u5409\u897f\u4ed6\u6ee8\/\u987a\u94c2\uff09\u662f\u57fa\u4e8e\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u968f\u673a\u7814\u7a76\u3002<\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">[1] <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf<\/a>.<\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u5173\u4e8e\u98df\u7ba1\u764c<\/strong><\/p>\n\n\n\n<p>\u98df\u7ba1\u764c\u662f\u6d88\u5316\u9053\u9886\u57df\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u7edf\u8ba1\uff0c\u98df\u7ba1\u764c\u662f2020\u5e74\u5168\u7403\u7b2c\u4e03\u5927\u5e38\u89c1\u6076\u6027\u80bf\u7624\u548c\u7b2c\u516d\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\uff0c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc760\u4e07\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6570\u8d85\u8fc754\u4e07<sup>[1]<\/sup>\u3002\u98df\u7ba1\u9cde\u764c\uff08ESCC\uff09\u548c\u817a\u764c\u662f\u98df\u7ba1\u764c\u7684\u4e24\u79cd\u4e3b\u8981\u7ec4\u7ec7\u5b66\u4e9a\u578b\u3002\u65b0\u8fd1\u66f4\u65b0\u7684ESMO\u6307\u5357\u63a8\u8350\u94c2\u7c7b\u548c\u6c1f\u5c3f\u5627\u5576\u7c7b\u53cc\u836f\u8054\u5408PD-1\u963b\u65ad\u6027\u6297\u4f53\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC<sup>[2]<\/sup>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u76ee\u524d\u5df2\u5728\u6b27\u7f8e\u83b7\u6279\u8be5\u9886\u57df\u6cbb\u7597\u7684\u514d\u75ab\u7597\u6cd5\u9002\u5e94\u75c7\u4ec5\u9002\u7528ESCC\u7684\u90e8\u5206\u4eba\u7fa4\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6848\u6765\u5ef6\u957fESCC\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u7279\u522b\u662fPD-L1\u4f4e\u8868\u8fbe\u4eba\u7fa4\u3002<\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">[1] <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf<\/a>.<\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">[2] Obermannova R,Alsina M, Cervantes A,Leong T,Lordick F, Nilsson M,van Greeken NCT, Vogel A,Smyth EC; ESMO Guidelines Committee. ESMO Clinical Practice Guidline for diagnosis,treatment and follow-up.Ann Oncol.2022 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