{"id":1997,"date":"2022-08-25T06:46:13","date_gmt":"2022-08-25T06:46:13","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=1997"},"modified":"2023-03-17T06:52:18","modified_gmt":"2023-03-17T06:52:18","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9js110%ef%bc%88xpo1%e6%8a%91%e5%88%b6%e5%89%82%ef%bc%89%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%94%b3%e8%af%b7%e8%8e%b7%e5%be%97%e7%be%8e%e5%9b%bdfda%e6%89%b9-2","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9js110%ef%bc%88xpo1%e6%8a%91%e5%88%b6%e5%89%82%ef%bc%89%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%94%b3%e8%af%b7%e8%8e%b7%e5%be%97%e7%be%8e%e5%9b%bdfda%e6%89%b9-2\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269JS110\uff08XPO1\u6291\u5236\u5242\uff09\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6"},"content":{"rendered":"\n
\u5317\u4eac\u65f6\u95f42022\u5e748\u670825\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u4e0e\u5fae\u5883\u751f\u7269\u5171\u540c\u5f00\u53d1\u7684XPO1\u6291\u5236\u5242WJ01024\u7247\uff08\u9879\u76ee\u4ee3\u53f7\uff1aJS110\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u3002\u622a\u81f3\u76ee\u524d\uff0c\u541b\u5b9e\u751f\u7269\u7684\u7814\u53d1\u7ba1\u7ebf\u4e0a\u5171\u67097\u6b3e\u521b\u65b0\u836f\u7269\u83b7\u51c6\u5728\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n\n\n
XPO1\u662f\u4ecb\u5bfc\u6838\u8f93\u51fa\u7684\u4e3b\u8981\u86cb\u767d\uff0c\u5728\u7ef4\u6301\u7ec6\u80de\u7a33\u6001\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002XPO1\u901a\u8fc7\u4e0e\u6838\u5b54\u590d\u5408\u7269\u4e2d\u7684\u6838\u5b54\u86cb\u767d\uff08NUP214\u548cNUP88\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u5c06\u542b\u6709\u6838\u8f93\u51fa\u4fe1\u53f7\uff08Nuclear export signals\uff0cNES\uff09\u7684\u86cb\u767d\uff0c\u548cRNA\u8fd0\u8f93\u51fa\u7ec6\u80de\u6838\u3002XPO1\u7684\u8f6c\u8fd0\u5e95\u7269\u5305\u62ec\u591a\u79cd\u6291\u764c\u86cb\u767d\u548c\u591a\u79cd\u81f4\u764c\u57fa\u56e0\u7684mRNA\u3002\u7814\u7a76\u8868\u660e\uff0cXPO1\u5728\u9aa8\u9ad3\u7624\u3001\u6dcb\u5df4\u7624\u3001\u5375\u5de2\u764c\u3001\u8111\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u9aa8\u8089\u7624\u3001\u80f0\u817a\u764c\u3001\u5bab\u9888\u764c\u548c\u80c3\u764c\u7b49\u591a\u79cd\u6076\u6027\u80bf\u7624\u4e2d\u8fc7\u8868\u8fbe\uff0c\u901a\u8fc7\u8f6c\u8fd0\u591a\u79cd\u6291\u764c\u8f6c\u5f55\u56e0\u5b50\u548c\u4fc3\u764c\u57fa\u56e0\u7684mRNA\u7684\u51fa\u6838\uff0c\u4ece\u800c\u963b\u65ad\u6291\u764c\u901a\u8def\u548c\u6fc0\u6d3b\u4fc3\u764c\u901a\u8def\uff0c\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u548c\u5b58\u6d3b\u3002\u7814\u7a76\u8868\u660e\uff0c\u6291\u5236XPO1\u53ef\u4ee5\u6062\u590d\u80bf\u7624\u6291\u5236\u86cb\u767d\u7684\u529f\u80fd\uff0c\u6291\u5236\u4fc3\u764c\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u8fdb\u800c\u6cbb\u7597\u80bf\u76241<\/sup>\u3002<\/p>\n\n\n\n JS110\u662f\u6838\u8f93\u51fa\u86cb\u767dXPO1\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u4e34\u5e8a\u4e0a\u62df\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80bf\u7624\u75c5\u4eba\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cJS110\u7279\u5f02\u6027\u963b\u65adXPO1\u86cb\u767d\u529f\u80fd\uff0c\u6291\u5236\u5305\u62ecp53\u5728\u5185\u591a\u79cd\u6291\u764c\u86cb\u767d\u51fa\u6838\uff0c\u52a0\u5f3a\u6291\u764c\u86cb\u767d\u529f\u80fd\u3002JS110\u4f53\u5916\u6291\u5236\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u751f\u957f\uff0c\u8bf1\u53d1\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u5728\u80bf\u7624\u52a8\u7269\u6a21\u578b\u4e2d\uff0cJS110\u5355\u836f\u6216\u8005\u8054\u7528\u53ef\u6291\u5236\u591a\u79cd\u8840\u6db2\u548c\u5b9e\u4f53\u80bf\u7624\u751f\u957f\u3002\u7531\u4e8e\u5176\u72ec\u7279\u7684\u4f5c\u7528\u673a\u5236\uff0cJS110\u7684\u5f00\u53d1\u6709\u671b\u7ed9\u665a\u671f\u80bf\u7624\u75c5\u4eba\u5e26\u6765\u5168\u65b0\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n\n\n\n 2021\u5e744\u6708\uff0cJS110\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002\u76ee\u524d\uff0cJS110\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04991129\uff09\u3002\u541b\u5b9e\u751f\u7269\u62e5\u6709JS110\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u72ec\u5bb6\u751f\u4ea7\u6743\u3001\u59d4\u6258\u751f\u4ea7\u6743\u53ca\u9500\u552e\u6743\u3002<\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u5317\u4eac\u65f6\u95f42022\u5e748\u670825\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u4e0e\u5fae\u5883\u751f\u7269\u5171\u540c\u5f00\u53d1\u7684XPO1\u6291\u5236\u5242WJ01024\u7247\uff08\u9879\u76ee\u4ee3\u53f7\uff1aJS110\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u3002\u622a\u81f3\u76ee\u524d\uff0c\u541b\u5b9e\u751f\u7269\u7684\u7814\u53d1\u7ba1\u7ebf\u4e0a\u5171\u67097\u6b3e\u521b\u65b0\u836f\u7269\u83b7\u51c6\u5728\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n","protected":false},"author":3,"featured_media":1209,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1"],"yoast_head":"\n\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1. Gravina GL, Senapedis W, McCauley D, et al. Nucleo-cytoplasmic transport as a therapeutic target of cancer. J Hematol Oncol, 2014. 7: 85.<\/h5>\n\n\n\n
1. \u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n\n\n