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<\/p>\n\n\n\n

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Tifcemalimab\uff08TAB004\/JS004\uff09\u662f\u541b\u5b9e\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff08first-in-human\uff09\u7684\u6297\u80bf\u7624\u91cd\u7ec4\u4eba\u6e90\u5316\u6297BTLA\uff08B\u548cT\u6dcb\u5df4\u7ec6\u80de\u8870\u51cf\u56e0\u5b50\uff09\u5355\u514b\u9686\u6297\u4f53\u3002\u76ee\u524d\uff0ctifcemalimab\u5df2\u8fdb\u5165Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u591a\u9879\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u540c\u6b65\u5f00\u5c55\u4e2d\uff0c\u8986\u76d6\u591a\u4e2a\u7624\u79cd\u3002<\/p>\n\n\n\n

Tifcemalimab\u6240\u9488\u5bf9\u7684BTLA\u9776\u70b9\u4e8e2003\u5e74\u53d1\u73b0\uff0c\u4e3aCD28\u53d7\u4f53\u5bb6\u65cf\u6210\u5458[1]<\/sup>\u3002\u5b83\u5177\u6709\u5355\u4e2aIgSF V\u7ec6\u80de\u5916\u57df\uff0c\u5176\u5e8f\u5217\u4e0e\u5176\u4ed6CD28\u5bb6\u65cf\u5206\u5b50\uff08\u4f8b\u5982PD-1\u548cCTLA-4\uff09\u5177\u6709\u76f8\u4f3c\u6027\u3002<\/p>\n\n\n\n

BTLA\u5728T\u548cB\u6dcb\u5df4\u7ec6\u80de\u4ee5\u53ca\u6811\u7a81\u72b6\u7ec6\u80de\u4e9a\u7fa4\u4e0a\u8868\u8fbe\u3002BTLA\u4e0e\u5176\u914d\u4f53HVEM\uff08Herpes virus entry mediator\uff0c\u75b1\u75b9\u75c5\u6bd2\u4fb5\u5165\u4ecb\u8d28\uff09\u7684\u76f8\u4e92\u4f5c\u7528\u4e8e2005\u5e74\u88ab\u53d1\u73b0\uff0cHVEM\u662f\u5728\u9020\u8840\u7cfb\u7edf\u4e2d\u5e7f\u6cdb\u8868\u8fbe\u7684TNF\u53d7\u4f53\uff0c\u88ab\u786e\u5b9a\u4e3aBTLA\u7684\u914d\u4f53[2]<\/sup>\u3002<\/p>\n\n\n\n

BTLA\u662f\u4e00\u79cd\u514d\u75ab\u7403\u86cb\u767d\u76f8\u5173\u6027\u819c\u86cb\u767d\uff0c\u5176\u86cb\u767d\u7ed3\u6784\u7c7b\u4f3c\u4e8e\u8de8\u819c\u53d7\u4f53CTLA-4\u548cPD-1\u3002\u5728\u6b63\u5e38\u751f\u7406\u60c5\u51b5\u4e0b\uff0cBTLA\u4e0e\u5176\u914d\u4f53HVEM\u7ed3\u5408\u540e\uff0c\u53ef\u4ee5\u6291\u5236\u6dcb\u5df4\u7ec6\u80de\u7684\u8fc7\u5ea6\u6d3b\u5316\uff0c\u9632\u6b62\u514d\u75ab\u7cfb\u7edf\u5bf9\u81ea\u8eab\u7684\u635f\u4f24[2]<\/sup>\u3002<\/p>\n\n\n\n

Tifcemalimab\u901a\u8fc7\u7ed3\u5408BTLA\uff0c\u963b\u65adHVEM-BTLA\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u963b\u65adBTLA\u4ecb\u5bfc\u7684\u6291\u5236\u6027\u4fe1\u53f7\u901a\u8def\uff0c\u6700\u7ec8\u8fbe\u5230\u6fc0\u6d3b\u80bf\u7624\u7279\u5f02\u6dcb\u5df4\u7ec6\u80de\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
[1] Watanabe, N., Gavrieli, M., Sedy, J.R., Yang,J., Fallarino, F., Loftin, S.K., Hurchla, M.A., Zimmerman, N., Sim, J., Zang, X., et al. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4, 670-679.<\/h5>\n\n\n\n
[2] Sedy, J.R., Gavrieli, M., Potter, K.G., Hurchla, M.A., Lindsley, R.C., Hildner, K., Scheu, S., Pfeffer, K., Ware, C.F., Murphy, T.L., et al. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 6, 90-98.<\/h5>\n\n\n\n

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