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href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzU5NTQ3ODUxMg==&mid=2247485969&idx=1&sn=f32df1f146d413bb81130a56427e6ed1&chksm=fe70188ec9079198545f9ef80875202c5eaa8ea7ece03c28c7dca1f3785fa1c8aed32c4c0101&token=1241584977&lang=zh_CN&scene=21#wechat_redirect\">#LBA2<\/a>\uff09\uff0c\u968f\u540e\u8363\u767b\u300a<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzU5NTQ3ODUxMg==&mid=2247486421&idx=1&sn=d93ae2e67651a23819175d8b38dd395b&chksm=fe70194ac907905c1dcaed08c62089481ac557a76227c08cad2f8ff8179550798186946514d6&token=1241584977&lang=zh_CN&scene=21#wechat_redirect\">\u81ea\u7136-\u533b\u5b66<\/a>\u300b\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a58.7\uff09\u6742\u5fd7\u5c01\u9762\uff0c\u5e76\u83b7\u5f97\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\uff08<em>Journal of the American Medical Association<\/em>\uff0c<em>JAMA<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a63.1\uff09\u5168\u6587\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4f7f\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u964d\u4f4e48%\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e37%\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u5ef6\u957f\u4e8613.2\u4e2a\u6708\uff0c\u4ece8.2\u4e2a\u6708\u63d0\u5347\u523021.4\u4e2a\u6708\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u8be5\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u83b7\u5f97\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u66f4\u957f\u7684\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DoR\uff09\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u957f\u671f\u751f\u5b58\u968f\u8bbf\u6570\u636e\u57282024\u5e74ASCO\u5e74\u4f1a\u5c55\u793a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u7ec45\u5e74\u751f\u5b58\u7387\u8fbe\u523052.0%\u3002<\/p>\n\n\n\n<p>POLARIS-02\u7814\u7a76\u7ed3\u679c\u5df2\u4e8e2021\u5e741\u6708\u5728\u7ebf\u53d1\u8868\u4e8e\u300a<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzU5NTQ3ODUxMg==&mid=2247485605&idx=1&sn=7ef0e06c0712611df966eb600e36a0b0&chksm=fe701a3ac907932c68c9357d923765501929ba528dc7fdb2a66f40f5d790d950864bf2ec742a&token=1302660704&lang=zh_CN#rd\">\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7<\/a>\u300b\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a42.1\uff09\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u65e2\u5f80\u5316\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u60a3\u8005ORR\u4e3a20.5%\uff0cDoR\u4e3a12.8\u4e2a\u6708\uff0c\u4e2d\u4f4dOS\u8fbe17.4\u4e2a\u6708\u3002<\/p>\n\n\n\n<p>\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u5185\u5730\u3001\u4e2d\u56fd\u9999\u6e2f\u3001\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u5370\u5ea6\u7b49\u8d85\u8fc730\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5206\u522b\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u665a\u671f\u9f3b\u54bd\u764c\u7684\u6cbb\u7597\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u836f\u7269\uff0c\u4e5f\u662f\u7f8e\u56fd\u548c\u6b27\u6d32\u5730\u533a\u9996\u4e2a\u4e14\u552f\u4e00\u7528\u4e8e\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u836f\u7269\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e0a\u5e02\u7533\u8bf7\u4e5f\u5728\u82f1\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65b0\u52a0\u5761\u3001\u5df4\u897f\u3001\u54e5\u4f26\u6bd4\u4e9a\u3001\u5357\u975e\u3001\u667a\u5229\u3001\u7ea6\u65e6\u3001\u9a6c\u6765\u897f\u4e9a\u3001\u6cf0\u56fd\u3001\u5370\u5ea6\u5c3c\u897f\u4e9a\u3001\u83f2\u5f8b\u5bbe\u63d0\u4ea4\/\u53d7\u7406\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><em>2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3010\u53c2\u8003\u6587\u732e\u3011<\/p>\n\n\n\n<p>1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/4-nasopharynx-fact-sheet.pdf.<\/p>\n\n\n\n<p><\/p>\n\n\n\n\n\n<p><strong>\u5173\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09<\/strong><\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u4f5c\u4e3a\u6211\u56fd\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u4e2a\u56fd\u4ea7\u4ee5PD-1\u4e3a\u9776\u70b9\u7684\u5355\u6297\u836f\u7269\uff0c\u83b7\u5f97\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u9879\u76ee\u652f\u6301\uff0c\u5e76\u8363\u81ba\u56fd\u5bb6\u4e13\u5229\u9886\u57df\u6700\u9ad8\u5956\u9879\u201c\u4e2d\u56fd\u4e13\u5229\u91d1\u5956\u201d\u3002<\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u5355\u6297\u81f3\u4eca\u5df2\u5728\u5168\u7403\uff08\u5305\u62ec\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u4e1c\u5357\u4e9a\u53ca\u6b27\u6d32\u7b49\u5730\uff09\u5f00\u5c55\u4e86\u8986\u76d6\u8d85\u8fc715\u4e2a\u9002\u5e94\u75c7\u768440\u591a\u9879\u7531\u516c\u53f8\u53d1\u8d77\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u6b63\u5728\u8fdb\u884c\u6216\u5df2\u5b8c\u6210\u7684\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u5728\u591a\u4e2a\u7624\u79cd\u8303\u56f4\u5185\u8bc4\u4f30\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9f3b\u54bd\u764c\u3001\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u3001\u80be\u764c\u53ca\u76ae\u80a4\u764c\u7b49\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u5185\u5730\u83b7\u627910\u9879\u9002\u5e94\u75c7\uff1a\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\uff082018\u5e7412\u6708\uff09\uff1b\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff082021\u5e742\u6708\uff09\uff1b\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u759712\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\uff082021\u5e744\u6708\uff09\uff1b\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff082021\u5e7411\u6708\uff09\uff1b\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u590d\u53d1\u6216\u8fdc\u5904\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff082022\u5e745\u6708\uff09\uff1b\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9634\u6027\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff082022\u5e749\u6708\uff09\uff1b\u8054\u5408\u5316\u7597\u56f4\u624b\u672f\u671f\u6cbb\u7597\uff0c\u7ee7\u4e4b\u672c\u54c1\u5355\u836f\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\uff0c\u7528\u4e8e\u53ef\u5207\u9664IIIA-IIIB\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6210\u4eba\u60a3\u8005\uff082023\u5e7412\u6708\uff09\uff1b\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u4e2d\u9ad8\u5371\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff082024\u5e744\u6708\uff09\uff1b\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u94c2\u7c7b\u7528\u4e8e\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff082024\u5e746\u6708\uff09\uff1b\u8054\u5408\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b\uff09\u7528\u4e8e\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u8bc4\u4f30PD-L1\u9633\u6027\uff08CPS\u22651\uff09\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff082024\u5e746\u6708\uff09\u30022020\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u9996\u6b21\u901a\u8fc7\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\uff0c\u76ee\u524d\u5df2\u67096\u9879\u83b7\u6279\u9002\u5e94\u75c7\u7eb3\u5165\u300a\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff082023\u5e74\uff09\u300b\uff0c\u662f\u76ee\u5f55\u4e2d\u552f\u4e00\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u30022024\u5e7410\u6708\uff0c\u9999\u6e2f\u836f\u5242\u4e1a\u53ca\u6bd2\u836f\u7ba1\u7406\u5c40\uff08PPB\uff09\u6279\u51c6\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e0a\u5e02\u7533\u8bf7\u7528\u4e8e\u590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