{"id":3127,"date":"2024-11-15T11:33:59","date_gmt":"2024-11-15T03:33:59","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=3127"},"modified":"2024-11-18T11:39:12","modified_gmt":"2024-11-18T03:39:12","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97extentorch%e7%a0%94%e7%a9%b6%e5%9c%a8%e5%9b%bd%e9%99%85%e6%9d%83%e5%a8%81%e6%9c%9f%e5%88%8ajama%e5%ad%90","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97extentorch%e7%a0%94%e7%a9%b6%e5%9c%a8%e5%9b%bd%e9%99%85%e6%9d%83%e5%a8%81%e6%9c%9f%e5%88%8ajama%e5%ad%90\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u7279\u745e\u666e\u5229\u5355\u6297EXTENTORCH\u7814\u7a76\u5728\u56fd\u9645\u6743\u5a01\u671f\u520aJAMA\u5b50\u520a\u53d1\u8868"},"content":{"rendered":"\n<p>\u5f53\u5730\u65f6\u95f411\u670814\u65e5\uff0c\u7531\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388\u7275\u5934\u5f00\u5c55\u7684\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c (ES-SCLC) \u7684III\u671fEXTENTORCH\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u56fd\u9645\u80bf\u7624\u5b66\u9876\u7ea7\u671f\u520a\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u00b7\u80bf\u7624\u5b66\u300b (<em>JAMA Oncology<\/em>\uff0cIF<sub>2023<\/sub>=22.5\uff09\uff0c\u4e3aES-SCLC\u4e00\u7ebf\u514d\u75ab\u6cbb\u7597\u518d\u6dfb\u91cd\u78c5\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u3002\u7a0b\u9896\u6559\u6388\u4e3a\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u548c\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"3011\" height=\"1698\" src=\"https:\/\/www.junshipharma.com\/wp-content\/uploads\/2024\/11\/\u63d2\u56fe.png\" alt=\"\" class=\"wp-image-3128\"\/><\/figure>\n\n\n\n<p>EXTENTORCH\u7814\u7a76\uff08NCT04012606\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u53ca\u94c2\u7c7b\u4e00\u7ebf\u6cbb\u7597ES-SCLC\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p>EXTENTORCH\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\uff0c<strong>\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201cEXTENTORCH\u7814\u7a76\u4f5c\u4e3aES-SCLC\u9886\u57df\u5168\u7403\u9996\u4e2a\u6210\u529f\u8fbe\u5230\u9884\u8bbe\u53cc\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u9633\u6027\u7ed3\u679c\u7684\u6297PD-1\u5355\u6297\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u662fES-SCLC\u6cbb\u7597\u7684\u53c8\u4e00\u6b21\u5173\u952e\u7a81\u7834\u3002 \u8bd5\u9a8c\u7ec41\u5e74PFS\u7387\u63d0\u5347\u8fd14\u500d\uff0c\u6240\u6709\u4e9a\u7ec4\u60a3\u8005\u5747\u6709\u83b7\u76ca\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e4b\u4e00\u7684OS\u53d6\u5f97\u9633\u6027\u7ed3\u679c\uff0c\u6210\u529f\u901a\u8fc7\u4e86\u4e34\u5e8a\u201c\u91d1\u6807\u51c6\u201d\u7684\u8003\u6838\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u786e\u5207\u751f\u5b58\u83b7\u76ca\u3002\u672c\u6b21EXTENTORCH\u7814\u7a76\u89c1\u520a\u4e0d\u4ec5\u516c\u5e03\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597ES-SCLC\u7684\u7597\u6548\u6570\u636e\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u8fdb\u884c\u4e86\u5206\u5b50\u5c42\u9762\u7684\u63a2\u7d22\uff0c\u5bf9\u7b5b\u9009\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\u5177\u6709\u91cd\u8981\u7684\u6307\u5bfc\u610f\u4e49\u3002\u201d<\/p>\n\n\n\n<p><a>2023<\/a>\u5e745\u6708\uff0cEXTENTORCH\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5747\u8fbe\u5230\u65b9\u6848\u9884\u8bbe\u7684\u4f18\u6548\u8fb9\u754c\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7531\u6b64\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u5728ES-SCLC\u4e00\u7ebf\u6cbb\u7597III\u671f\u7814\u7a76\u4e2d\u53d6\u5f97\u9884\u8bbe\u53cc\u91cd\u4e3b\u8981\u7ec8\u70b9\u9633\u6027\u7ed3\u679c\u7684PD-1\u6291\u5236\u5242\u3002<\/p>\n\n\n\n<p>2024\u5e746\u6708\uff0c\u57fa\u4e8e\u8be5\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6b63\u5f0f\u6279\u51c6\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u94c2\u7c7b\u7528\u4e8e<a>ES-SCLC<\/a>\u4e00\u7ebf\u6cbb\u7597\uff0c\u5e76\u83b7\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u4e24\u5927\u6307\u5357\u63a8\u8350\u4e3aES-SCLC\u4e00\u7ebf\u6cbb\u7597\u4f18\u9009\u65b9\u6848\uff0c\u4e3a\u4e2d\u56fdES-SCLC\u60a3\u8005\u63d0\u4f9b\u4e86\u6cbb\u7597\u65b0\u9009\u62e9\u3002<\/p>\n\n\n\n<p>\u6b64\u524d\uff0cEXTENTORCH\u7814\u7a76\u4ee5\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u57282023\u5e74ESMO\u5927\u4f1a\u4e0a\u9996\u6b21\u516c\u5e03\u4e86\u7814\u7a76\u6570\u636e\uff0c\u6b64\u6b21\u5168\u6587\u53d1\u8868\u4e8e\u56fd\u9645\u671f\u520a\uff0c\u5f70\u663e\u4e86\u56fd\u9645\u5b66\u8005\u5bf9\u8fd9\u9879\u7814\u7a76\u53ca\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u80af\u5b9a\uff0c\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u663e\u8457\u6539\u5584\u60a3\u8005PFS\u548cOS\uff0c\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e33%\uff08HR=0.67\uff1b95% CI\uff0c 0.54-0.82\uff09\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8620%\uff08HR=0.80\uff1b95% CI\uff0c 0.65-0.98\uff09\u3002\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c\u6240\u6709\u5173\u952e\u4e9a\u7ec4\u5747\u663e\u793a\u51fa\u4e00\u81f4\u7684PFS\u548cOS\u83b7\u76ca\u3002<\/li>\n\n\n\n<li>\u751f\u7269\u6807\u5fd7\u7269\u63a2\u7d22\u5206\u6790\u663e\u793a\uff0c\u5728\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u4e2d\uff0c\u5177\u6709\u4f4e\u80bf\u7624\u5185\u5f02\u8d28\u6027\uff08ITH\uff09\uff0c<em>HLA-A11<sup>+<\/sup> HLA-B62<sup>&#8211;<\/sup><\/em>\u5355\u500d\u578b\uff0c<em>KMT2D \u548cCOL4A4<\/em>\u91ce\u751f\u578b\uff0c\u6216<em>CTNNA2\/SCN4A<\/em>\u5e8f\u5217\u53d8\u5f02\u7684\u60a3\u8005\u7684\u4e34\u5e8a\u83b7\u76ca\u66f4\u660e\u663e\u3002<\/li>\n\n\n\n<li>\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002\u4e24\u7ec4\u5728\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff0c99.5%vs100%\uff09\u548c\u22653\u7ea7TEAE\uff0889.6%vs89.4%\uff09\u7684\u53d1\u751f\u7387\u76f8\u4f3c\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u603b\u7ecf\u7406\u517c\u9996\u5e2d\u6267\u884c\u5b98\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a:&#8221;\u6b64\u6b21EXTENTORCH\u7684\u91cd\u78c5\u7814\u7a76\u6210\u679c\u83b7\u5f97\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u00b7\u80bf\u7624\u5b66\u300b\u53d1\u8868\uff0c\u4f53\u73b0\u4e86\u56fd\u9645\u5b66\u672f\u754c\u5bf9\u4ee5\u7279\u745e\u666e\u5229\u5355\u6297\u4e3a\u4ee3\u8868\u7684\u514d\u75ab\u6cbb\u7597\u5728ES-SCLC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u4ef7\u503c\u8ba4\u53ef\u3002\u80ba\u764c\u4e00\u76f4\u662f\u516c\u53f8\u91cd\u70b9\u5173\u6ce8\u7684\u75be\u75c5\u9886\u57df\uff0c\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u6210\u529f\u83b7\u6279\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u5728\u5185\u76843\u9879\u9002\u5e94\u75c7\uff0c\u8986\u76d6\u4e86\u65e9\u4e2d\u671f\uff08\u56f4\u624b\u672f\u671f\uff09\u81f3\u665a\u671f\u4eba\u7fa4\uff0c\u7ba1\u7ebf\u5185\u4e5f\u8fd8\u6709\u5176\u4ed6\u4ea7\u54c1\u6b63\u5904\u4e8e\u653b\u5173\u9636\u6bb5\uff0c\u6211\u4eec\u4f1a\u79ef\u6781\u63a8\u8fdb\u76f8\u5173\u5de5\u4f5c\uff0c\u671f\u5f85\u80fd\u4e3a\u5168\u7403\u80ba\u764c\u60a3\u8005\u5e26\u6765\u66f4\u591a\u66f4\u4f18\u7684\u521b\u65b0\u65b9\u6848\u3002\u201d<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. 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