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\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u662f\u5f9e\u96a8\u6a5f\u81f3\u6301\u7e8c\u81e8\u5e8a\u6062\u5fa9\u7684\u6642\u9593\uff0c\u98a8\u96aa\u6bd4\uff08HR\uff09\u5169\u507495%\u7f6e\u4fe1\u5340\u9593\uff08CI\uff09\u4e0b\u9650>0.8\u5b9a\u7fa9\u70ba\u975e\u52a3\u6548\u6027\u3002\u6b21\u8981\u7642\u6548\u7d42\u9ede\u5305\u62ec\u622a\u81f3\u7b2c28\u5929\u9032\u5c55\u70ba\u91cd\u5ea6\/\u5371\u91cdCOVID-19\u6216\u5168\u56e0\u6b7b\u4ea1\u7684\u60a3\u8005\u6bd4\u4f8b\uff0cCOVID-19\u76f8\u95dc\u75c7\u72c0\u8a55\u5206\u548cWHO\u81e8\u5e8a\u9032\u5c55\u91cf\u8868\u8a55\u5206\u8b8a\u5316\u3001\u81f3\u6301\u7e8c\u75c7\u72c0\u6d88\u5931\u7684\u6642\u9593\u3001SARS-CoV-2\u6838\u9178\u9670\u6027\u6642\u9593\u7b49\u3002\u5b89\u5168\u6027\u7d42\u9ede\u5305\u62ec\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u548c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u60c5\u6cc1\u3002<\/p>\n\n\n\n

\u6839\u64da\u6700\u7d42\u5206\u6790\u7d50\u679c\uff08\u622a\u81f32022\u5e748\u670818\u65e5\uff09\uff0c\u5728FAS\u4eba\u7fa4\u4e2d\uff0cVV116\u8207PAXLOVID\u5728\u201c\u81f3\u6301\u7e8c\u81e8\u5e8a\u6062\u5fa9\u7684\u6642\u9593\u201d\u9054\u5230\u975e\u52a3\u6548\uff08HR=1.17\uff0c95%CI\uff1a1.02~1.36\uff09\uff0c\u4e14VV116\u7d44\u6bd4PAXLOVID\u7d44\u7684\u4e2d\u4f4d\u6062\u5fa9\u6642\u9593\u66f4\u77ed\uff084\u5929 vs. 5\u5929\uff09\u3002<\/p>\n\n\n\n

VV116\u7d44\u548cPAXLOVID\u7d44\u5728\u201c\u81f3\u6301\u7e8c\u75c7\u72c0\u6d88\u5931\u7684\u6642\u9593\u201d\u3001\u201c\u81f3\u9996\u6b21SARS-CoV-2\u6838\u9178\u9670\u6027\u6642\u9593\u201d\u65b9\u9762\u8868\u73fe\u985e\u4f3c\uff0c\u4e2d\u4f4d\u6642\u9593\u5747\u70ba7\u5929\u3002\u5728\u6bcf\u4e00\u500b\u9810\u8a2d\u6642\u9593\u9ede\uff08\u7b2c5\u30017\u300110\u300114\u300128\u5929\uff09\uff0cVV116\u7d44\u75c7\u72c0\u7de9\u89e3\u7684\u60a3\u8005\u6bd4\u4f8b\u5747\u9ad8\u65bcPAXLOVID\u7d44\u3002\u5169\u7d44\u60a3\u8005\u5747\u672a\u767c\u751f\u9032\u5c55\u70ba\u91cd\u5ea6\/\u5371\u91cdCOVID-19\u6216\u6b7b\u4ea1\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0c\u672c\u7814\u7a76\u4e2d\u7d043\/4\u7684\u60a3\u8005\u66fe\u63a5\u7a2e\u904e\u65b0\u51a0\u75ab\u82d7\uff0c\u800c\u6b64\u985e\u60a3\u8005\u5728\u5927\u591a\u6578\u7684\u7814\u7a76\u4e2d\u6703\u88ab\u6392\u9664\u5728\u5916\uff0c\u4e9e\u7d44\u5206\u6790\u7d50\u679c\u986f\u793a\uff0cVV116\u548cPAXLOVID\u5728\u63a5\u7a2e\u6216\u672a\u63a5\u7a2e\u75ab\u82d7\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u7d50\u679c\u7121\u7d71\u8a08\u5b78\u5dee\u7570\u3002<\/p>\n\n\n\n

\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cVV116\u6bd4PAXLOVID\u7684\u5b89\u5168\u6027\u9867\u616e\u66f4\u5c11\u3002VV116\u7d44\u7684AE\u767c\u751f\u7387\u4f4e\u65bcPAXLOVID\u7d44\uff08\u6240\u6709\u7d1a\u5225\u7684AE\uff1a67.4% vs. 77.3%\uff0c3\u62164\u7d1aAE\uff1a2.6% vs. 5.7%\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cPAXLOVID\u8207\u591a\u7a2e\u85e5\u7269\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff08Drug-drug interaction\uff09\uff0c\u800cVV116\u4e0d\u6703\u6291\u5236\u6216\u8a98\u5c0e\u4e3b\u8981\u85e5\u7269\u4ee3\u8b1d\u9176\uff0c\u6216\u8005\u6291\u5236\u4e3b\u8981\u85e5\u7269\u8f49\u904b\u86cb\u767d\uff0c\u56e0\u6b64\u8207\u5408\u4f75\u7528\u85e5\u767c\u751f\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u6027\u5c0f\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/h5>\n\n\n\n
1. Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.
2. Qian, Hj., et al. Acta Pharmacol Sin (2022).
3. Shen Y, et al. Emerg Microbes Infect 2022;11:1518-23.
4. <\/strong>\u6b64\u6b21\u53c3\u8207\u7814\u7a76\u76847\u5bb6\u65b0\u51a0\u80ba\u708e\u5b9a\u9ede\u91ab\u9662\u5206\u5225\u70ba\uff1a\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u745e\u91d1\u91ab\u9662\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u4ec1\u6fdf\u91ab\u9662\u3001\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u6d66\u6771\u91ab\u9662\u3001\u4e0a\u6d77\u516c\u5171\u885b\u751f\u81e8\u5e8a\u4e2d\u5fc3\u3001\u4e0a\u6d77\u4e2d\u91ab\u85e5\u5927\u5b78\u9644\u5c6c\u66d9\u5149\u91ab\u9662\u3001\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u540c\u4ec1\u91ab\u9662<\/h5>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n\n\n\n

1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/h6>\n\n\n\n

<\/p>\n\n\n\n\n\n

\u95dc\u65bc<\/strong>VV116<\/strong>\uff08<\/strong>JT001<\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n

VV116\u662f\u4e00\u6b3e\u53e3\u670d\u6838\u82f7\u985e\u85e5\u7269\uff0c\u53ef\u6291\u5236SARS-CoV-2\u8907\u88fd\u3002\u81e8\u5e8a\u524d\u85e5\u6548\u5b78\u7814\u7a76\u986f\u793a\uff0cVV116\u5728\u9ad4\u5916\u5c0d\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u548c\u5df2\u77e5\u7a81\u8b8a\u682a\u90fd\u8868\u73fe\u51fa\u986f\u8457\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff1b\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u4f4e\u5291\u91cf\u7684VV116\u5c31\u53ef\u5c07\u80ba\u90e8\u75c5\u6bd2\u6ef4\u5ea6\u964d\u4f4e\u81f3\u6aa2\u6e2c\u9650\u4ee5\u4e0b\uff0c\u53ef\u986f\u8457\u6539\u5584\u80ba\u7d44\u7e54\u75c5\u7406\u8b8a\u5316\uff0c\u8868\u73fe\u51fa\u8f03\u5f37\u7684\u6297\u75c5\u6bd2\u529f\u6548\u3002\u81e8\u5e8a\u524d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7b49\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cVV116\u5177\u6709\u5f88\u9ad8\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u53e3\u670d\u5438\u6536\u5f8c\uff0c\u8fc5\u901f\u4ee3\u8b1d\u70ba\u6bcd\u9ad4\u6838\u82f7\uff0c\u4e26\u5728\u9ad4\u5167\u7d44\u7e54\u5ee3\u6cdb\u5206\u4f48\u3002<\/p>\n\n\n\n

VV116\u7531\u4e2d\u570b\u79d1\u5b78\u9662\u4e0a\u6d77\u85e5\u7269\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u6b66\u6f22\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u65b0\u7586\u7406\u5316\u6280\u8853\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u4e2d\u4e9e\u85e5\u7269\u7814\u767c\u4e2d\u5fc3\/\u4e2d\u70cf\u91ab\u85e5\u79d1\u6280\u57ce\uff08\u79d1\u6280\u90e8\u201c\u4e00\u5e36\u4e00\u8def\u201d\u806f\u5408\u5be6\u9a57\u5ba4\uff09\u3001\u81e8\u6e2f\u5be6\u9a57\u5ba4\u3001\u8607\u5dde\u65fa\u5c71\u65fa\u6c34\u751f\u7269\u91ab\u85e5\u6709\u9650\u516c\u53f8\uff08\u65fa\u5c71\u65fa\u6c34\uff09\u548c\u541b\u5be6\u751f\u7269\u5171\u540c\u7814\u767c\u3002\u541b\u5be6\u751f\u7269\u8207\u65fa\u5c71\u65fa\u6c34\u5171\u540c\u627f\u64d4\u8a72\u85e5\u7269\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\u548c\u7522\u696d\u5316\u5de5\u4f5c\uff0c\u5408\u4f5c\u5340\u57df\u70ba\u9664\u4e2d\u4e9e\u4e94\u570b\u3001\u4fc4\u7f85\u65af\u3001\u5317\u975e\u3001\u4e2d\u6771\u56db\u500b\u5340\u57df\u5916\u7684\u5168\u7403\u7bc4\u570d\u3002<\/p>\n\n\n\n

\u541b\u5be6\u751f\u7269\u8207\u65fa\u5c71\u65fa\u6c34\u5df2\u5728\u4e2d\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u4e2d\u5b8c\u6210\u4e863\u9805I\u671f\u7814\u7a76[1]<\/sup>\uff0c\u4e26\u5728\u4e2d\u570b\u8f15\/\u4e2d\u5ea6COVID-19\u9ad8\u98a8\u96aa\u60a3\u8005\u4e2d\u5b8c\u62101\u9805III\u671f\u7814\u7a76[2]<\/sup>\uff08NCT05341609\uff09\uff0c\u7814\u7a76\u7d50\u679c\u5206\u5225\u767c\u8868\u65bcActa Pharmacologica Sinica\u548c\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08The New England Journal of Medicine<\/em>\uff09\u3002<\/p>\n\n\n\n

2021\u5e74\uff0cVV116\u5728\u70cf\u8332\u5225\u514b\u65af\u5766\u7372\u5f97\u6279\u51c6\u7528\u65bc\u4e2d\/\u91cd\u5ea6COVID-19\u60a3\u8005\u7684\u6cbb\u7642\u3002<\/p>\n\n\n\n

\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
[1] Qian, Hj., et al. Acta Pharmacol Sin (2022).<\/h5>\n\n\n\n
[2] Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<\/h5>\n\n\n\n

<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

\u5317\u4eac\u6642\u95932022\u5e7412\u670829\u65e5\uff0c\u5168\u7403\u6b0a\u5a01\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08The New England Journal of Medicine\uff0cNEJM\uff0c\u5f71\u97ff\u56e0\u6578\uff1a176.079\uff09\u7dda\u4e0a\u767c\u8868\u4e86\u541b\u5be6\u751f\u7269\u65d7\u4e0b\u7684\u53e3\u670d\u6838\u82f7\u985e\u6297\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u85e5\u7269VV116\uff08JT001\uff09\u5c0d\u6bd4\u5948\u746a\u7279\u97cb\u7247\/\u5229\u6258\u90a3\u97cb\u7247\u7d44\u5408\u85e5\u7269\uff08PAXLOVID\uff09\u7528\u65bc\u4f34\u6709\u9032\u5c55\u70ba\u91cd\u5ea6\u5305\u62ec\u6b7b\u4ea1\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u8f15\u81f3\u4e2d\u5ea6\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\uff08COVID-19\uff09\u60a3\u8005\u65e9\u671f\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05341609\uff09\u6210\u679c 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