{"id":1979,"date":"2022-11-24T06:03:51","date_gmt":"2022-11-24T06:03:51","guid":{"rendered":"https:\/\/www.junshipharma.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e3%80%8a%e6%96%b0%e8%8b%b1%e6%a0%bc%e5%85%b0%e5%8c%bb%e5%ad%a6%e6%9d%82%e5%bf%97%e3%80%8b%e5%8f%91%e8%a1%a8%e5%8f%a3%e6%9c%8d%e6%8a%97%e6%96%b0\/"},"modified":"2023-03-17T06:12:57","modified_gmt":"2023-03-17T06:12:57","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e3%80%8a%e6%96%b0%e8%8b%b1%e6%a0%bc%e5%85%b0%e5%8c%bb%e5%ad%a6%e6%9d%82%e5%bf%97%e3%80%8b%e5%8f%91%e8%a1%a8%e5%8f%a3%e6%9c%8d%e6%8a%97%e6%96%b0","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/zh-hant\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e3%80%8a%e6%96%b0%e8%8b%b1%e6%a0%bc%e5%85%b0%e5%8c%bb%e5%ad%a6%e6%9d%82%e5%bf%97%e3%80%8b%e5%8f%91%e8%a1%a8%e5%8f%a3%e6%9c%8d%e6%8a%97%e6%96%b0\/","title":{"rendered":"\u541b\u5be6\u751f\u7269\u5ba3\u4f48\u5df2\u5411\u82f1\u570b\u85e5\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\u63d0\u4ea4\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>\u9019\u662f\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u6b50\u6d32\u5730\u5340\u7684\u7b2c\u4e8c\u9805\u4e0a\u5e02\u7533\u8acb\uff0c\u5176\u5168\u7403\u5546\u696d\u5316\u5de5\u4f5c\u6b63\u5728\u7a69\u6b65\u63a8\u9032<\/em><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5317\u4eac\u6642\u95932022\u5e7411\u670824\u65e5\uff0c\u541b\u5be6\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u4e8e\u8fd1\u65e5\u5411\u82f1\u570b\u85e5\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u63d0\u4ea4\u6297PD-1\u55ae\u6297\u85e5\u7269\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u3002\u6b64\u6b21\u7533\u5831\u7684\u9069\u61c9\u75c7\u5206\u5225\u70ba\uff1a1\uff09\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u5c40\u90e8\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b2\uff09\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u9806\u9251\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\uff08ESCC\uff09\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u6b64\u524d\uff0c\u541b\u5be6\u751f\u7269\u5df2\u5411\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u63d0\u4ea4\u4e86\u9019\u5169\u9805\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u3002<\/p>\n\n\n\n<p><strong>\u541b\u5be6\u751f\u7269\u9996\u5e2d\u91ab\u5b78\u5b98<\/strong><strong>Patricia Keegan<\/strong><strong>\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u672c\u6708\uff0c\u6211\u5011\u5148\u5f8c\u5411\u6b50\u6d32\u5169\u5927\u76e3\u7ba1\u6a5f\u69cb\u63d0\u4ea4\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u4e0a\u5e02\u7533\u8acb\uff0c\u9019\u9ad4\u73fe\u4e86\u516c\u53f8\u81f4\u529b\u63a8\u52d5\u5275\u65b0\u85e5\u7269\u9020\u798f\u5168\u7403\u60a3\u8005\u7684\u5805\u5b9a\u6c7a\u5fc3\u4ee5\u53ca\u9ad8\u6548\u7684\u57f7\u884c\u529b\u3002\u5f8c\u7e8c\u6211\u5011\u5c07\u8207\u82f1\u570b\u76e3\u7ba1\u6a5f\u69cb\u9032\u884c\u7dca\u5bc6\u5408\u4f5c\uff0c\u7a4d\u6975\u63a8\u52d5\u65b0\u8208\u7642\u6cd5\u5728\u7576\u5730\u7684\u81e8\u5e8a\u958b\u767c\u8207\u61c9\u7528\u3002\u201d<\/p>\n\n\n\n<p>\u6b64\u6b21NPC\u548cESCC\u9069\u61c9\u75c7\u7684\u7533\u5831\u5206\u5225\u57fa\u65bcJUPITER-02\uff08\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\uff0cNCT03581786\uff09\u548cJUPITER-06\uff08\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u7814\u7a76\uff0cNCT03829969\uff09\u7684\u7814\u7a76\u7d50\u679c\u3002<\/p>\n\n\n\n<p>JUPITER-02\u6210\u679c\u57282021\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u7684\u5168\u9ad4\u5927\u6703\u4e0a\u9996\u6b21\u767c\u8868\uff08#LBA2\uff09\uff0c\u96a8\u5f8c\u4f5c\u70ba<a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01444-0\">\u300a\u81ea\u7136-\u91ab\u5b78\u300b<\/a>\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a87.241\uff092021\u5e749\u6708\u520a\u7684\u5c01\u9762\u6587\u7ae0\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5c0d\u65bc\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6027\u6cbb\u7642\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027NPC\u60a3\u8005\uff0c\u8207\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u7d44\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff0c\u70ba21.4 vs. 8.2\u500b\u6708\uff0c\u5ef6\u957713.2\u500b\u6708\uff0c\u4e26\u4e14\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u53ef\u964d\u4f4e48%\u7684\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff08HR=0.52\uff0c95%CI\uff1a0.37-0.73\uff0c\u96d9\u5074p<0.0001\uff09\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u665a\u671fNPC\u4e00\u7dda\u548c\u5f8c\u7dda\u6cbb\u7642\u7684\u5169\u9805\u9069\u61c9\u75c7\u5df2\u5728\u4e2d\u570b\u7372\u5f97\u6279\u51c6\uff0c\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u8a72\u9818\u57df\u6cbb\u7642\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08ICI\uff09\u3002\u5728\u570b\u969b\u4e0a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7684NPC\u9069\u61c9\u75c7\u66fe\u88ab\u7f8e\u570b\u548c\u6b50\u76df\u76e3\u7ba1\u6a5f\u69cb\u7d2f\u8a08\u6388\u4e882\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u548c2\u9805\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u7f8e\u570b\u7684\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u6b63\u5728\u5be9\u8a55\u4e2d\uff0c\u6709\u671b\u6210\u70ba\u8a72\u570b\u9996\u500b\u4e14\u552f\u4e00\u7528\u65bc\u9f3b\u54bd\u764c\u6cbb\u7642\u7684\u85e5\u7269\u3002 JUPITER-06\u6210\u679c\u5247\u5728\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5e74\u6703\uff08ESMO 2021\uff09\u4e0a\u4ee5\u53e3\u982d\u5f59\u5831\u5f62\u5f0f\u9996\u6b21\u4eae\u76f8\uff0c\u96a8\u5f8c\u5728\u570b\u969b\u9802\u5c16\u816b\u7624\u5b78\u96dc\u8a8c<a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(22)00059-9\">\u300aCancer Cell\u300b<\/a>\uff08\u5f71\u97ff\u56e0\u6578\uff1a38.585\uff09\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u5c0d\u65bc\u672a\u7d93\u7cfb\u7d71\u6027\u5316\u7642\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\uff0c\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u8b93\u66f4\u591a\u60a3\u8005\u7372\u5f97\u4e86\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\uff0c\u5176\u4e2d\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5927\u5e45\u5ef6\u9577\u81f317\u500b\u6708\uff0c\u5c0d\u6bd4\u5c0d\u7167\u7d44\u55ae\u7d14\u5316\u7642\u5ef6\u9577\u4e866\u500b\u6708\uff0c\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e42%\uff08HR=0.58\uff0cP\uff1c0.0001\uff09\uff0c\u4e14\u7121\u8ad6\u60a3\u8005PD-L1\u8868\u9054\u5982\u4f55\uff0c\u5747\u53ef\u7372\u76ca\u3002\u57fa\u65bc\u4e0a\u8ff0\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u4e00\u7dda\u6cbb\u7642\u665a\u671fESCC\u9069\u61c9\u75c7\u5728\u4e2d\u570b\u7372\u6279\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u98df\u7ba1\u764c\u4e5f\u66fe\u7372\u5f97\u7f8e\u570b\u76e3\u7ba1\u6a5f\u69cb\u6388\u4e88\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\"><em>2. <em>\u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/em><\/h6>\n\n\n\n\n\n<p><strong>\u95dc\u65bc\u9f3b\u54bd\u764c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u7a2e\u539f\u767c\u65bc\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u60e1\u6027\u816b\u7624\uff0c\u662f\u5e38\u898b\u7684\u982d\u9838\u90e8\u816b\u7624\u4e4b\u4e00\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u7d71\u8a08\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e13\u842c<sup>[1]<\/sup>\u3002\u7531\u65bc\u539f\u767c\u816b\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u63a1\u7528\u624b\u8853\u6cbb\u7642\uff0c\u5c40\u90e8\u75be\u75c5\u60a3\u8005\u4e3b\u8981\u63a1\u7528\u5316\u7642\u53ca\u653e\u7642\u6cbb\u7642\u3002\u5728\u7f8e\u570b\u548c\u6b50\u6d32\uff0c\u76ee\u524d\u5c1a\u7121\u85e5\u7269\u7372\u6279\u7528\u65bc\u6cbb\u7642\u9f3b\u54bd\u764c\uff0c\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff08\u5409\u897f\u4ed6\u6ff1\/\u9806\u9251\uff09\u662f\u57fa\u65bc\u5728\u4e2d\u570b\u958b\u5c55\u7684\u96a8\u6a5f\u7814\u7a76\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">[1] <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf<\/a>.<\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u98df\u7ba1\u764c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u98df\u7ba1\u764c\u662f\u6d88\u5316\u9053\u9818\u57df\u6700\u5e38\u898b\u7684\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u3002\u64da\u7d71\u8a08\uff0c\u98df\u7ba1\u764c\u662f2020\u5e74\u5168\u7403\u7b2c\u4e03\u5927\u5e38\u898b\u60e1\u6027\u816b\u7624\u548c\u7b2c\u516d\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\uff0c\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e60\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6578\u8d85\u904e54\u842c<sup>[1]<\/sup>\u3002\u98df\u7ba1\u9c57\u764c\uff08ESCC\uff09\u548c\u817a\u764c\u662f\u98df\u7ba1\u764c\u7684\u5169\u7a2e\u4e3b\u8981\u7d44\u7e54\u5b78\u4e9e\u578b\u3002\u65b0\u8fd1\u66f4\u65b0\u7684ESMO\u6307\u5357\u63a8\u85a6\u9251\u985e\u548c\u6c1f\u5c3f\u5627\u5576\u985e\u96d9\u85e5\u806f\u5408PD-1\u963b\u65b7\u6027\u6297\u9ad4\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC<sup>[2]<\/sup>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u76ee\u524d\u5df2\u5728\u6b50\u7f8e\u7372\u6279\u8a72\u9818\u57df\u6cbb\u7642\u7684\u514d\u75ab\u7642\u6cd5\u9069\u61c9\u75c7\u50c5\u9069\u7528ESCC\u7684\u90e8\u5206\u4eba\u7fa4\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u85e5\u7269\u548c\u6cbb\u7642\u65b9\u6848\u4f86\u5ef6\u9577ESCC\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u7279\u5225\u662fPD-L1\u4f4e\u8868\u9054\u4eba\u7fa4\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">[1] <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf<\/a>.<\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\">[2] Obermannova R,Alsina M, Cervantes A,Leong T,Lordick F, Nilsson M,van Greeken NCT, Vogel A,Smyth EC; ESMO Guidelines Committee. ESMO Clinical Practice Guidline for diagnosis,treatment and follow-up.Ann Oncol.2022 Oct;33(10):992-1004. 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